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 ==Glucokinase==
---[[User:Student|Student]] 07:51, 4 March 2009 (IST)Niva Ran and Tinuke Adeyemi
+The enzyme glucokinase facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in the liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for the enzyme use in type 2 diabetes treatment.
-==General Information==
+===Structure==={{STRUCTURE_1v4s|  PDB=1v4s  |  SCENE=  }}
-Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are important for its playing the role of a glucose sensor in pancreas and liver. Its structures also revealed an allosteric site through which small molecules may modulate the kinetic properties of the enzyme. This finding provided the mechanistic basis for activation of glucokinase as a potential therapeutic approach for treating type 2 diabetes mellitus.
+The glucokinase has 18 <scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene> (unless we counted wrong), 13 <scene name='Sandbox22/Beta_sheets/5'>beta sheets</scene> (this one is for sure), and 3 <scene name='Sandbox22/Ligands/1'>ligands</scene>: a <scene name='Sandbox22/Sodium_ion/1'>sodium ion</scene>, <scene name='Sandbox22/Glc/1'>T2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide</scene>
+amide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.
-===Structure===
+Purple denotes all the <scene name='Sandbox22/Polar/2'>polar</scene> sections of the protein: the hydrophillic areas that dominate the outer surface which comes in contact with aqueous environments. In this view we can see very neatly how the beta sheets alternate in polarity in a 'zigzag manner, and how the alpha helices are roughly 2-3 polar (while the inner protein is obviously hydrophobic). The
+<scene name='Sandbox22/Spacefill/2'>spacefill representation</scene>, in particular, shows how the surface is dominantly hydrophillic.
-{{STRUCTURE_1v4s|  PDB=1v4s  |  SCENE=  }}
+===Reference===
+http://www.proteopedia.org/wiki/index.php/1v4s
+http://en.wikipedia.org/wiki/Glucokinase
-<scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene>
-<scene name='Sandbox22/Beta_sheets/3'>beta sheets</scene>
-<scene name='Sandbox22/Ligands/1'>ligands</scene>
-===Reference===
+--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran
-http://www.proteopedia.org/wiki/index.php/1v4s