2f8m: Difference between revisions

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-{{Seed}}
-[[Image:2f8m.png|left|200px]]
-<!--
+==Ribose 5-phosphate isomerase from Plasmodium falciparum==
-The line below this paragraph, containing "STRUCTURE_2f8m", creates the "Structure Box" on the page.
+<StructureSection load='2f8m' size='340' side='right'caption='[[2f8m]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2f8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8M FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.087&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_2f8m|  PDB=2f8m  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8m OCA], [https://pdbe.org/2f8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8m RCSB], [https://www.ebi.ac.uk/pdbsum/2f8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8m ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RPIA_PLAF7 RPIA_PLAF7] Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.[UniProtKB:P0A7Z0]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8m_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8m ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of ribose 5-phosphate isomerase from Plasmodium falciparum, PFE0730c, has been determined by molecular replacement at 2.09 angstroms resolution. The enzyme, which catalyzes the isomerization reaction that interconverts ribose 5-phosphate and ribulose 5-phosphate, is a member of the pentose phosphate pathway. The P. falciparum enzyme belongs to the ribose 5-phosphate isomerase A family, Pfam family PF06562 (DUF1124), and is structurally similar to other members of the family.
-===Ribose 5-phosphate isomerase from Plasmodium falciparum===
+Structure of ribose 5-phosphate isomerase from Plasmodium falciparum.,Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F, Schoenfeld LW, Earnest TN, Hol WG, Merritt EA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):427-31. Epub 2006 Apr 12. PMID:16682767<ref>PMID:16682767</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2f8m" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_16682767}}, adds the Publication Abstract to the page
+*[[Ribose-5-phosphate isomerase 3D structures|Ribose-5-phosphate isomerase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16682767 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16682767}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-F8M is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8M OCA].
+[[Category: Plasmodium falciparum 3D7]]
+[[Category: Holmes MA]]
-==Reference==
+[[Category: Merritt EA]]
-<ref group="xtra">PMID:16682767</ref><references group="xtra"/>
-[[Category: Plasmodium falciparum 3d7]]
-[[Category: Ribose-5-phosphate isomerase]]
-[[Category: Holmes, M A.]]
-[[Category: Merritt, E A.]]
-[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Sgpp]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics of pathogenic protozoa consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:16:17 2009''