1a7g: Difference between revisions

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[[Image:1a7g.png|left|200px]]


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==THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS==
The line below this paragraph, containing "STRUCTURE_1a7g", creates the "Structure Box" on the page.
<StructureSection load='1a7g' size='340' side='right'caption='[[1a7g]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1a7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_31 Human papillomavirus 31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1a7g| PDB=1a7g |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7g OCA], [https://pdbe.org/1a7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7g RCSB], [https://www.ebi.ac.uk/pdbsum/1a7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VE2_HPV31 VE2_HPV31] E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/1a7g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a7g ConSurf].
<div style="clear:both"></div>


===THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS===
==See Also==
 
*[[Regulatory protein E2|Regulatory protein E2]]
 
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_10089498}}, adds the Publication Abstract to the page
[[Category: Human papillomavirus 31]]
(as it appears on PubMed at http://www.pubmed.gov), where 10089498 is the PubMed ID number.
[[Category: Large Structures]]
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[[Category: Bussiere DE]]
{{ABSTRACT_PUBMED_10089498}}
[[Category: Giranda VL]]
 
==About this Structure==
1A7G is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_31 Human papillomavirus type 31]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7G OCA].
 
==Reference==
<ref group="xtra">PMID:10089498</ref><references group="xtra"/>
[[Category: Human papillomavirus type 31]]
[[Category: Bussiere, D E.]]
[[Category: Giranda, V L.]]
[[Category: Cervical cancer]]
[[Category: E2]]
[[Category: Papillomavirus]]
[[Category: Transcription regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:01:43 2009''

Latest revision as of 09:28, 7 February 2024

THE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMSTHE CRYSTAL STRUCTURE OF THE E2 DNA-BINDING DOMAIN FROM HUMAN PAPILLOMAVIRUS AT 2.4 ANGSTROMS

Structural highlights

1a7g is a 1 chain structure with sequence from Human papillomavirus 31. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VE2_HPV31 E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1a7g, resolution 2.40Å

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