2jm6: Difference between revisions

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-{{Seed}}
-[[Image:2jm6.png|left|200px]]
-<!--
+==Solution structure of MCL-1 complexed with NOXAB==
-The line below this paragraph, containing "STRUCTURE_2jm6", creates the "Structure Box" on the page.
+<StructureSection load='2jm6' size='340' side='right'caption='[[2jm6]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2jm6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JM6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm6 OCA], [https://pdbe.org/2jm6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jm6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jm6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jm6 ProSAT]</span></td></tr>
-{{STRUCTURE_2jm6|  PDB=2jm6  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/APR_MOUSE APR_MOUSE] Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1 (By similarity). Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1.<ref>PMID:10807576</ref> <ref>PMID:15901672</ref> <ref>PMID:15694340</ref> <ref>PMID:16822983</ref> <ref>PMID:17389404</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jm6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jm6 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
-===Solution structure of MCL-1 complexed with NOXAB===
+Structural insights into the degradation of Mcl-1 induced by BH3 domains.,Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404<ref>PMID:17389404</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2jm6" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17389404}}, adds the Publication Abstract to the page
+*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17389404 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17389404}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-JM6 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JM6 OCA].
-==Reference==
-<ref group="xtra">PMID:17389404</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Colman, P M.]]
+[[Category: Colman PM]]
-[[Category: Czabotar, P E.]]
+[[Category: Czabotar PE]]
-[[Category: Day, C L.]]
+[[Category: Day CL]]
-[[Category: Delft, M F.van.]]
+[[Category: Fairlie WD]]
-[[Category: Fairlie, W D.]]
+[[Category: Hinds MG]]
-[[Category: Hinds, M G.]]
+[[Category: Huang DCS]]
-[[Category: Huang, D C.S.]]
+[[Category: Lee EF]]
-[[Category: Lee, E F.]]
+[[Category: Smith BJ]]
-[[Category: Smith, B J.]]
+[[Category: Van Delft MF]]
-[[Category: Apoptosis]]
-[[Category: Bcl-2]]
-[[Category: Bh3-only]]
-[[Category: Helical bundle]]
-[[Category: Mcl-1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:37:04 2009''