1bn6: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1bn6.gif|left|200px]]<br />
-<applet load="1bn6" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1bn6, resolution 1.5&Aring;" />
-'''HALOALKANE DEHALOGENASE FROM A RHODOCOCCUS SPECIES'''<br />
-==Overview==
+==HALOALKANE DEHALOGENASE FROM A RHODOCOCCUS SPECIES==
-The hydrolytic haloalkane dehalogenases are promising bioremediation and, biocatalytic agents. Two general classes of dehalogenases have been, reported from Xanthobacter and Rhodococcus. While these enzymes share 30%, amino acid sequence identity, they have significantly different substrate, specificities and halide-binding properties. We report the 1.5 A, resolution crystal structure of the Rhodococcus dehalogenase at pH 5.5, pH, 7.0, and pH 5.5 in the presence of NaI. The Rhodococcus and Xanthobacter, enzymes have significant structural homology in the alpha/beta hydrolase, core, but differ considerably in the cap domain. Consistent with its broad, specificity for primary, secondary, and cyclic haloalkanes, the, Rhodococcus enzyme has a substantially larger active site cavity., ... [[http://ispc.weizmann.ac.il/pmbin/getpm?10587433 (full description)]]
+<StructureSection load='1bn6' size='340' side='right'caption='[[1bn6]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1bn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn6 OCA], [https://pdbe.org/1bn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DHAA_RHOSD DHAA_RHOSD]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/1bn6_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bn6 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-BN6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rhodococcus_sp. Rhodococcus sp.]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.5 3.8.1.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BN6 OCA]].
+*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Haloalkane dehalogenases: structure of a Rhodococcus enzyme., Newman J, Peat TS, Richard R, Kan L, Swanson PE, Affholter JA, Holmes IH, Schindler JF, Unkefer CJ, Terwilliger TC, Biochemistry. 1999 Dec 7;38(49):16105-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10587433 10587433]
+[[Category: Large Structures]]
-[[Category: Rhodococcus sp.]]
+[[Category: Rhodococcus sp]]
-[[Category: Single protein]]
+[[Category: Affholter JA]]
-[[Category: Affholter, J.A.]]
+[[Category: Holmes IH]]
-[[Category: Holmes, I.H.]]
+[[Category: Kan L]]
-[[Category: Kan, L.]]
+[[Category: Newman J]]
-[[Category: Newman, J.]]
+[[Category: Peat TS]]
-[[Category: Peat, T.S.]]
+[[Category: Richard R]]
-[[Category: Richard, R.]]
+[[Category: Schindler JF]]
-[[Category: Schindler, J.F.]]
+[[Category: Swanson PE]]
-[[Category: Swanson, P.E.]]
+[[Category: Terwilliger TC]]
-[[Category: Terwilliger, T.C.]]
+[[Category: Unkefer CJ]]
-[[Category: Unkefer, C.J.]]
-[[Category: alpha/beta-hydrolase]]
-[[Category: crystal structure]]
-[[Category: dehalogenase]]
-[[Category: dhla]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 22:04:27 2007''