2g8d: Difference between revisions

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New page: left|200px<br /><applet load="2g8d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g8d, resolution 2.40Å" /> '''Lactobacillus casei ...
 
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[[Image:2g8d.gif|left|200px]]<br /><applet load="2g8d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g8d, resolution 2.40&Aring;" />
'''Lactobacillus casei thymidylate synthase Y261W-dUMP complex'''<br />


==About this Structure==
==Lactobacillus casei thymidylate synthase Y261W-dUMP complex==
2G8D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei] with UMP as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA].
<StructureSection load='2g8d' size='340' side='right'caption='[[2g8d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
[[Category: Lactobacillus casei]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2g8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8D FirstGlance]. <br>
[[Category: Thymidylate synthase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
[[Category: Finer-Moore, J.S.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
[[Category: Stroud, R.M.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8d OCA], [https://pdbe.org/2g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8d RCSB], [https://www.ebi.ac.uk/pdbsum/2g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8d ProSAT]</span></td></tr>
[[Category: UMP]]
</table>
[[Category: active site mutation]]
== Function ==
[[Category: alpha/beta protein]]
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
[[Category: beta sheet]]
== Evolutionary Conservation ==
[[Category: dump complex]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: methyltransferase]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8d ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:01:41 2007''
==See Also==
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Finer-Moore JS]]
[[Category: Stroud RM]]

Latest revision as of 12:26, 14 February 2024

Lactobacillus casei thymidylate synthase Y261W-dUMP complexLactobacillus casei thymidylate synthase Y261W-dUMP complex

Structural highlights

2g8d is a 1 chain structure with sequence from Lacticaseibacillus casei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_LACCA Provides the sole de novo source of dTMP for DNA biosynthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2g8d, resolution 2.40Å

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