2a4f: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:2a4f.png|left|200px]]
-<!--
+==Synthesis and Activity of N-Axyl Azacyclic Urea HIV-1 Protease Inhibitors with High Potency Against Multiple Drug Resistant Viral Strains.==
-The line below this paragraph, containing "STRUCTURE_2a4f", creates the "Structure Box" on the page.
+<StructureSection load='2a4f' size='340' side='right'caption='[[2a4f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2a4f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4F FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAU:(5R,6R)-5-BENZYL-6-HYDROXY-2,4-BIS(4-HYDROXY-3-METHOXYBENZYL)-1-[3-(4-HYDROXYPHENYL)PROPANOYL]-1,2,4-TRIAZEPAN-3-ONE'>AAU</scene></td></tr>
-{{STRUCTURE_2a4f|  PDB=2a4f  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4f OCA], [https://pdbe.org/2a4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4f RCSB], [https://www.ebi.ac.uk/pdbsum/2a4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4f ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9Q2G8_9HIV1 Q9Q2G8_9HIV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4f_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4f ConSurf].
+<div style="clear:both"></div>
-===Synthesis and Activity of N-Axyl Azacyclic Urea HIV-1 Protease Inhibitors with High Potency Against Multiple Drug Resistant Viral Strains.===
+==See Also==
+*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16203141}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 16203141 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_16203141}}
-==About this Structure==
-A4F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4F OCA].
-==Reference==
-<ref group="xtra">PMID:16203141</ref><references group="xtra"/>
-[[Category: HIV-1 retropepsin]]
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Lin, S.]]
+[[Category: Large Structures]]
-[[Category: McDonald, E.]]
+[[Category: Lin S]]
-[[Category: Mo, H.]]
+[[Category: McDonald E]]
-[[Category: Saldivar, A.]]
+[[Category: Mo H]]
-[[Category: Sham, H.]]
+[[Category: Saldivar A]]
-[[Category: Stewart, K D.]]
+[[Category: Sham H]]
-[[Category: Stoll, V.]]
+[[Category: Stewart KD]]
-[[Category: Sun, M.]]
+[[Category: Stoll V]]
-[[Category: Vasavanonda, S.]]
+[[Category: Sun M]]
-[[Category: Zhao, C.]]
+[[Category: Vasavanonda S]]
-[[Category: Aza-cyclic urea]]
+[[Category: Zhao C]]
-[[Category: Hiv protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 23:51:19 2009''