1xt5: Difference between revisions

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-{{Seed}}
-[[Image:1xt5.png|left|200px]]
-<!--
+==Crystal Structure of VCBP3, domain 1, from Branchiostoma floridae==
-The line below this paragraph, containing "STRUCTURE_1xt5", creates the "Structure Box" on the page.
+<StructureSection load='1xt5' size='340' side='right'caption='[[1xt5]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1xt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Branchiostoma_floridae Branchiostoma floridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XT5 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.15&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1xt5|  PDB=1xt5  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xt5 OCA], [https://pdbe.org/1xt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xt5 RCSB], [https://www.ebi.ac.uk/pdbsum/1xt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xt5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8I9N0_BRAFL Q8I9N0_BRAFL]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xt/1xt5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xt5 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.
-===Crystal Structure of VCBP3, domain 1, from Branchiostoma floridae===
+Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.,Hernandez Prada JA, Haire RN, Allaire M, Jakoncic J, Stojanoff V, Cannon JP, Litman GW, Ostrov DA Nat Immunol. 2006 Aug;7(8):875-82. Epub 2006 Jun 25. PMID:16799561<ref>PMID:16799561</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-XT5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Branchiostoma_floridae Branchiostoma floridae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XT5 OCA].
+<div class="pdbe-citations 1xt5" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Branchiostoma floridae]]
-[[Category: Allaire, M.]]
+[[Category: Large Structures]]
-[[Category: Cannon, J P.]]
+[[Category: Allaire M]]
-[[Category: Haire, R N.]]
+[[Category: Cannon JP]]
-[[Category: Jakoncic, J.]]
+[[Category: Haire RN]]
-[[Category: Litman, G W.]]
+[[Category: Hernandez Prada JA]]
-[[Category: Ostrov, D A.]]
+[[Category: Jakoncic J]]
-[[Category: Prada, J A.Hernandez.]]
+[[Category: Litman GW]]
-[[Category: Stojanoff, V.]]
+[[Category: Ostrov DA]]
-[[Category: Amphioxus]]
+[[Category: Stojanoff V]]
-[[Category: Florida lancelet]]
-[[Category: Innate immunity]]
-[[Category: Primordial antigen receptor]]
-[[Category: Vcbp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:19:58 2009''