2fyz: Difference between revisions

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-{{Seed}}
-[[Image:2fyz.png|left|200px]]
-<!--
+==Structural of Mumps virus fusion protein core==
-The line below this paragraph, containing "STRUCTURE_2fyz", creates the "Structure Box" on the page.
+<StructureSection load='2fyz' size='340' side='right'caption='[[2fyz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2fyz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mumps_orthorubulavirus Mumps orthorubulavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FYZ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fyz OCA], [https://pdbe.org/2fyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fyz RCSB], [https://www.ebi.ac.uk/pdbsum/2fyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fyz ProSAT]</span></td></tr>
-{{STRUCTURE_2fyz|  PDB=2fyz  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FUS_MUMPM FUS_MUMPM] Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with HN at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/2fyz_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fyz ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The fusion proteins of enveloped viruses mediating the fusion between the viral and cellular membranes comprise two discontinuous heptad repeat (HR) domains located at the ectodomain of the enveloped glycoproteins. The crystal structure of the fusion protein core of Mumps virus (MuV) was determined at 2.2 A resolution. The complex is a six-helix bundle in which three HR1 peptides form a central highly hydrophobic coiled-coil and three HR2 peptides pack against the hydrophobic grooves on the surface of central coiled-coil in an oblique antiparallel manner. Fusion core of MuV, like those of simian virus 5 and human respiratory syncytium virus, forms typical 3-4-4-4-3 spacing. The similar characterization in HR1 regions, as well as the existence of O-X-O motif in extended regions of HR2 helix, suggests a basic rule for the formation of the fusion core of viral fusion proteins.
-===Structural of Mumps virus fusion protein core===
+Structural characterization of mumps virus fusion protein core.,Liu Y, Xu Y, Lou Z, Zhu J, Hu X, Gao GF, Qiu B, Rao Z, Tien P Biochem Biophys Res Commun. 2006 Sep 29;348(3):916-22. Epub 2006 Aug 4. PMID:16904649<ref>PMID:16904649</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_16904649}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2fyz" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 16904649 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_16904649}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-FYZ is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Mumps_virus Mumps virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FYZ OCA].
+[[Category: Mumps orthorubulavirus]]
+[[Category: Liu Y]]
-==Reference==
+[[Category: Lou Z]]
-<ref group="xtra">PMID:16904649</ref><references group="xtra"/>
+[[Category: Rao Z]]
-[[Category: Mumps virus]]
+[[Category: Xu Y]]
-[[Category: Liu, Y.]]
-[[Category: Lou, Z.]]
-[[Category: Rao, Z.]]
-[[Category: Xu, Y.]]
-[[Category: Mumps virus fusion protein core]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:49:14 2009''