3eo2: Difference between revisions

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-{{Seed}}
-[[Image:3eo2.png|left|200px]]
-<!--
+==Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein==
-The line below this paragraph, containing "STRUCTURE_3eo2", creates the "Structure Box" on the page.
+<StructureSection load='3eo2' size='340' side='right'caption='[[3eo2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3eo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EO2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-{{STRUCTURE_3eo2|  PDB=3eo2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eo2 OCA], [https://pdbe.org/3eo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eo2 RCSB], [https://www.ebi.ac.uk/pdbsum/3eo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eo2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARHG8_HUMAN ARHG8_HUMAN] Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.<ref>PMID:21373644</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/3eo2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eo2 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of the RhoGEF domain of human neuroepithelial cell-transforming gene 1 protein===
+==See Also==
+*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-EO2 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EO2 OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bochkarev, A.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Bochkarev A]]
-[[Category: Edwards, A M.]]
+[[Category: Bountra C]]
-[[Category: MacKenzie, F.]]
+[[Category: Edwards AM]]
-[[Category: Nedyalkova, L.]]
+[[Category: MacKenzie F]]
-[[Category: Park, H.]]
+[[Category: Nedyalkova L]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Park H]]
-[[Category: Tempel, W.]]
+[[Category: Tempel W]]
-[[Category: Tong, Y.]]
+[[Category: Tong Y]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Alternative splicing]]
-[[Category: Cytoplasm]]
-[[Category: Guanine nucleotide exchange factor]]
-[[Category: Guanine-nucleotide releasing factor]]
-[[Category: Nucleus]]
-[[Category: Polymorphism]]
-[[Category: Proto-oncogene]]
-[[Category: Rhogef]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:38:07 2009''