1cws: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:1cws.png|left|200px]]
-<!--
+==HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE==
-The line below this paragraph, containing "STRUCTURE_1cws", creates the "Structure Box" on the page.
+<StructureSection load='1cws' size='340' side='right'caption='[[1cws]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CWS FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
-{{STRUCTURE_1cws|  PDB=1cws  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cws OCA], [https://pdbe.org/1cws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cws RCSB], [https://www.ebi.ac.uk/pdbsum/1cws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cws ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MPIP2_HUMAN MPIP2_HUMAN] Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.<ref>PMID:17332740</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cws_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cws ConSurf].
+<div style="clear:both"></div>
-===HUMAN CDC25B CATALYTIC DOMAIN WITH TUNGSTATE===
+==See Also==
+*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_10543950}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 10543950 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_10543950}}
-==About this Structure==
-CWS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWS OCA].
-==Reference==
-<ref group="xtra">PMID:10543950</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chidester, C G.]]
+[[Category: Large Structures]]
-[[Category: Reynolds, R A.]]
+[[Category: Chidester CG]]
-[[Category: Watenpaugh, K D.]]
+[[Category: Reynolds RA]]
-[[Category: Cdc25]]
+[[Category: Watenpaugh KD]]
-[[Category: Cdc25b]]
-[[Category: Cell cycle phosphatase]]
-[[Category: Dual specificity protein phosphatase]]
-[[Category: Hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:52:29 2009''