3bgl: Difference between revisions

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-{{Seed}}
-[[Image:3bgl.png|left|200px]]
-<!--
+==Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors==
-The line below this paragraph, containing "STRUCTURE_3bgl", creates the "Structure Box" on the page.
+<StructureSection load='3bgl' size='340' side='right'caption='[[3bgl]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3bgl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.225&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RID:(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC+ACID'>RID</scene></td></tr>
-{{STRUCTURE_3bgl|  PDB=3bgl  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgl OCA], [https://pdbe.org/3bgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgl RCSB], [https://www.ebi.ac.uk/pdbsum/3bgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgl ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgl ConSurf].
+<div style="clear:both"></div>
-===Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors===
+==See Also==
+*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_18155906}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 18155906 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_18155906}}
-==Disease==
-Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=142910 142910]]
-==About this Structure==
-BGL is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGL OCA].
-==Reference==
-<ref group="xtra">PMID:18155906</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Finzel, B C.]]
+[[Category: Large Structures]]
-[[Category: Park, W K.C.]]
+[[Category: Finzel BC]]
-[[Category: Pavlovsky, A.]]
+[[Category: Park WKC]]
-[[Category: Alternative splicing]]
+[[Category: Pavlovsky A]]
-[[Category: Cholesterol biosynthesis]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Glycoprotein]]
-[[Category: Hmg-coa]]
-[[Category: Lipid synthesis]]
-[[Category: Membrane]]
-[[Category: Nadph]]
-[[Category: Oxidoreductase]]
-[[Category: Peroxisome]]
-[[Category: Polymorphism]]
-[[Category: Statin]]
-[[Category: Steroid biosynthesis]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:46:10 2009''