1fkk: Difference between revisions

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-{{Seed}}
-[[Image:1fkk.png|left|200px]]
-<!--
+==ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN==
-The line below this paragraph, containing "STRUCTURE_1fkk", creates the "Structure Box" on the page.
+<StructureSection load='1fkk' size='340' side='right'caption='[[1fkk]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKK FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_1fkk|  PDB=1fkk  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkk OCA], [https://pdbe.org/1fkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkk RCSB], [https://www.ebi.ac.uk/pdbsum/1fkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FKB1A_BOVIN FKB1A_BOVIN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkk ConSurf].
+<div style="clear:both"></div>
-===ATOMIC STRUCTURE OF FKBP12, AN IMMUNOPHILIN BINDING PROTEIN===
+==See Also==
+*[[FKBP 3D structures|FKBP 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_15299838}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 15299838 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_15299838}}
-==About this Structure==
-FKK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKK OCA].
-==Reference==
-<ref group="xtra">PMID:15299838</ref><references group="xtra"/>
 [[Category: Bos taurus]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Large Structures]]
-[[Category: Navia, M A.]]
+[[Category: Navia MA]]
-[[Category: Sintchak, M D.]]
+[[Category: Sintchak MD]]
-[[Category: Thomson, J A.]]
+[[Category: Thomson JA]]
-[[Category: Wilson, K P.]]
+[[Category: Wilson KP]]
-[[Category: Cis-trans prolyl-isomerase]]
-[[Category: Fk506 binding protein]]
-[[Category: Fkbp12]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:43:54 2009''