3cc4: Difference between revisions

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[[Image:3cc4.png|left|200px]]


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==Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit==
The line below this paragraph, containing "STRUCTURE_3cc4", creates the "Structure Box" on the page.
<StructureSection load='3cc4' size='340' side='right'caption='[[3cc4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3cc4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CC4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=ANM:ANISOMYCIN'>ANM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
{{STRUCTURE_3cc4| PDB=3cc4 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc4 OCA], [https://pdbe.org/3cc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cc4 RCSB], [https://www.ebi.ac.uk/pdbsum/3cc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cc4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cc4 ConSurf].
<div style="clear:both"></div>


===Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit===
==See Also==
 
*[[Ribosome 3D structures|Ribosome 3D structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18455733}}
 
==About this Structure==
3CC4 is a 31 chains structure of sequences from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA].
 
==Reference==
<ref group="xtra">PMID:18455733</ref><ref group="xtra">PMID:12860128</ref><references group="xtra"/>
[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
[[Category: Blaha, G.]]
[[Category: Large Structures]]
[[Category: Gurel, G.]]
[[Category: Blaha G]]
[[Category: Anisomycin]]
[[Category: Gurel G]]
[[Category: Co-crystal]]
[[Category: Haloarcula marismortui]]
[[Category: Large ribosomal subunit]]
[[Category: Ribosome]]
[[Category: Wild type]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:48:58 2009''

Latest revision as of 12:34, 21 February 2024

Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal SubunitCo-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit

Structural highlights

3cc4 is a 10 chain structure with sequence from Haloarcula marismortui. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:, , , , , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RL2_HALMA One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3cc4, resolution 2.70Å

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