2ome: Difference between revisions

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{{Seed}}
[[Image:2ome.png|left|200px]]


<!--
==Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)==
The line below this paragraph, containing "STRUCTURE_2ome", creates the "Structure Box" on the page.
<StructureSection load='2ome' size='340' side='right'caption='[[2ome]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ome]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OME FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
{{STRUCTURE_2ome|  PDB=2ome  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ome FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ome OCA], [https://pdbe.org/2ome PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ome RCSB], [https://www.ebi.ac.uk/pdbsum/2ome PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ome ProSAT]</span></td></tr>
 
</table>
===Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)===
== Function ==
 
[https://www.uniprot.org/uniprot/CTBP2_HUMAN CTBP2_HUMAN] Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).  Isoform 2 probably acts as a scaffold for specialized synapses.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2OME is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OME OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/om/2ome_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ome ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Debreczeni, J E.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Debreczeni JE]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Guo, K.]]
[[Category: Guo K]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Pilka, E S.]]
[[Category: Pilka ES]]
[[Category: Rojkova, A.]]
[[Category: Rojkova A]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: C-terminal binding protein]]
[[Category: Ctbp2]]
[[Category: Dehydrogenase]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:53:52 2009''

Latest revision as of 13:43, 30 August 2023

Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H)

Structural highlights

2ome is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CTBP2_HUMAN Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2ome, resolution 2.80Å

Drag the structure with the mouse to rotate

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OCA
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