1moz: Difference between revisions

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-{{Seed}}
-[[Image:1moz.png|left|200px]]
-<!--
+==ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae==
-The line below this paragraph, containing "STRUCTURE_1moz", creates the "Structure Box" on the page.
+<StructureSection load='1moz' size='340' side='right'caption='[[1moz]], [[Resolution|resolution]] 3.17&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1moz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MOZ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.17&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-{{STRUCTURE_1moz|  PDB=1moz  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1moz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1moz OCA], [https://pdbe.org/1moz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1moz RCSB], [https://www.ebi.ac.uk/pdbsum/1moz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1moz ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ARL1_YEAST ARL1_YEAST] Recruits golgins such as IMH1 to the Golgi. Can bind and hydrolyze GTP. May be involved in trafficking events within the endosomal system.<ref>PMID:12052896</ref> <ref>PMID:12620188</ref> <ref>PMID:12620189</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/1moz_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1moz ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.
-===ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae===
+Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases.,Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602<ref>PMID:11535602</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_11535602}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1moz" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 11535602 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_11535602}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-MOZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA].
-==Reference==
-<ref group="xtra">PMID:11535602</ref><references group="xtra"/>
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Amor, J C.]]
+[[Category: Amor JC]]
-[[Category: Cheng, X.]]
+[[Category: Cheng X]]
-[[Category: Horton, J R.]]
+[[Category: Horton JR]]
-[[Category: Kahn, R A.]]
+[[Category: Kahn RA]]
-[[Category: Ringe, D.]]
+[[Category: Ringe D]]
-[[Category: Sullards, C.]]
+[[Category: Sullards C]]
-[[Category: Wang, Y.]]
+[[Category: Wang Y]]
-[[Category: Zhu, X.]]
+[[Category: Zhu X]]
-[[Category: Gtp-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:24:49 2009''