2d0q: Difference between revisions

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New page: left|200px<br /><applet load="2d0q" size="450" color="white" frame="true" align="right" spinBox="true" caption="2d0q, resolution 1.65Å" /> '''Complex of Fe-type N...
 
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[[Image:2d0q.gif|left|200px]]<br /><applet load="2d0q" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2d0q, resolution 1.65&Aring;" />
'''Complex of Fe-type NHase with Cyclohexyl isocyanide, photo-activated for 1hr at 277K'''<br />


==About this Structure==
==Complex of Fe-type NHase with Cyclohexyl isocyanide, photo-activated for 1hr at 277K==
2D0Q is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis] with FE, MG and CYI as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2D0Q OCA].  
<StructureSection load='2d0q' size='340' side='right'caption='[[2d0q]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
[[Category: Nitrile hydratase]]
== Structural highlights ==
[[Category: Protein complex]]
<table><tr><td colspan='2'>[[2d0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D0Q FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=CYI:CYCLOHEXYL+ISOCYANIDE'>CYI</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d0q OCA], [https://pdbe.org/2d0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d0q RCSB], [https://www.ebi.ac.uk/pdbsum/2d0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d0q ProSAT], [https://www.topsan.org/Proteins/RSGI/2d0q TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHAA_RHOER NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d0/2d0q_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d0q ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Nitrile hydratase|Nitrile hydratase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
[[Category: Hashimoto, K.]]
[[Category: Hashimoto K]]
[[Category: Kamiya, N.]]
[[Category: Kamiya N]]
[[Category: Kawano, Y.]]
[[Category: Kawano Y]]
[[Category: Nojiri, M.]]
[[Category: Nojiri M]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: CYI]]
[[Category: FE]]
[[Category: MG]]
[[Category: complex]]
[[Category: cysteine-sulfenic acid]]
[[Category: cysteine-sulfinic acid]]
[[Category: hydration]]
[[Category: national project on protein structural and functional analyses]]
[[Category: nitrile]]
[[Category: nppsfa]]
[[Category: photo-reactive]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
[[Category: substrate analogue]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 09:23:00 2007''

Latest revision as of 08:09, 17 October 2024

Complex of Fe-type NHase with Cyclohexyl isocyanide, photo-activated for 1hr at 277KComplex of Fe-type NHase with Cyclohexyl isocyanide, photo-activated for 1hr at 277K

Structural highlights

2d0q is a 2 chain structure with sequence from Rhodococcus erythropolis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.65Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NHAA_RHOER NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2d0q, resolution 1.65Å

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