2cy4: Difference between revisions
New page: left|200px<br /><applet load="2cy4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cy4, resolution 1.94Å" /> '''Crystal structure of... |
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== | ==Crystal structure of phosphotyrosine binding (PTB) domain of epidermal growth factor receptor pathway substrate-8 (EPS8) related protein 1 from Mus musculus (form-1 crystal)== | ||
<StructureSection load='2cy4' size='340' side='right'caption='[[2cy4]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2cy4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CY4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cy4 OCA], [https://pdbe.org/2cy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cy4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cy4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cy4 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ES8L1_MOUSE ES8L1_MOUSE] Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cy4_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cy4 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Epidermal growth factor receptor substrate 3D structures|Epidermal growth factor receptor substrate 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Hamana H]] | |||
[[Category: Hamana | [[Category: Kinoshita Y]] | ||
[[Category: Kinoshita | [[Category: Mizohata E]] | ||
[[Category: Mizohata | [[Category: Morita S]] | ||
[[Category: Morita | [[Category: Nagano K]] | ||
[[Category: Nagano | [[Category: Shirouzu M]] | ||
[[Category: Terada T]] | |||
[[Category: Shirouzu | [[Category: Uda H]] | ||
[[Category: Terada | [[Category: Yokoyama S]] | ||
[[Category: Uda | |||
[[Category: Yokoyama | |||
