2c2x: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2c2x.gif|left|200px]]<br /><applet load="2c2x" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2c2x, resolution 2.00&Aring;" />
-'''THREE DIMENSIONAL STRUCTURE OF BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE FROM MYCOBACTERIUM TUBERCULOSIS'''<br />
-==About this Structure==
+==Three dimensional structure of bifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Mycobacterium tuberculosis==
-C2X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA].
+<StructureSection load='2c2x' size='340' side='right'caption='[[2c2x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-[[Category: Mycobacterium tuberculosis]]
+== Structural highlights ==
-[[Category: Single protein]]
+<table><tr><td colspan='2'>[[2c2x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2X FirstGlance]. <br>
-[[Category: Javid-Majd, F.]]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-[[Category: Sacchettini, J.C.]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2x OCA], [https://pdbe.org/2c2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2x RCSB], [https://www.ebi.ac.uk/pdbsum/2c2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2x ProSAT], [https://www.topsan.org/Proteins/TBSGC/2c2x TOPSAN]</span></td></tr>
-[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
+</table>
-[[Category: cyclohydrolase]]
+== Function ==
-[[Category: hydrolase]]
+[https://www.uniprot.org/uniprot/FOLD_MYCTU FOLD_MYCTU] Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.[HAMAP-Rule:MF_01576]
-[[Category: methylenetetrahydrofolate dehydrogenase]]
+== Evolutionary Conservation ==
-[[Category: nadp]]
+[[Image:Consurf_key_small.gif|200px|right]]
-[[Category: oxidoreductase]]
+Check<jmol>
-[[Category: protein structure initiative]]
+  <jmolCheckbox>
-[[Category: psi]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2x_consurf.spt"</scriptWhenChecked>
-[[Category: tb structural genomics consortium]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: tbsgc]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: tetrahydrofolate]]
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2x ConSurf].
+<div style="clear:both"></div>
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:59:47 2007''
+==See Also==
+*[[Cyclohydrolase 3D structures|Cyclohydrolase 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
+[[Category: Javid-Majd F]]
+[[Category: Sacchettini JC]]