1r0x: Difference between revisions

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[[Image:1r0x.png|left|200px]]


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==Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP==
The line below this paragraph, containing "STRUCTURE_1r0x", creates the "Structure Box" on the page.
<StructureSection load='1r0x' size='340' side='right'caption='[[1r0x]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1r0x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R0X FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1r0x| PDB=1r0x |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r0x OCA], [https://pdbe.org/1r0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r0x RCSB], [https://www.ebi.ac.uk/pdbsum/1r0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r0x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CFTR_MOUSE CFTR_MOUSE] Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r0/1r0x_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r0x ConSurf].
<div style="clear:both"></div>


===Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP===
==See Also==
 
*[[ABC transporter 3D structures|ABC transporter 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_14685259}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 14685259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14685259}}
 
==About this Structure==
1R0X is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R0X OCA].
 
==Reference==
<ref group="xtra">PMID:14685259</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Buchanan, S G.]]
[[Category: Buchanan SG]]
[[Category: Burley, S K.]]
[[Category: Burley SK]]
[[Category: Conners, K.]]
[[Category: Conners K]]
[[Category: Dickey, M.]]
[[Category: Dickey M]]
[[Category: Dorwart, M.]]
[[Category: Dorwart M]]
[[Category: Fowler, R.]]
[[Category: Fowler R]]
[[Category: Gao, X.]]
[[Category: Gao X]]
[[Category: Guggino, W B.]]
[[Category: Guggino WB]]
[[Category: Hendrickson, W A.]]
[[Category: Hendrickson WA]]
[[Category: Lewis, H A.]]
[[Category: Lewis HA]]
[[Category: Abc transporter nucleotide binding domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:12:25 2009''

Latest revision as of 11:19, 14 February 2024

Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATPCystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP

Structural highlights

1r0x is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CFTR_MOUSE Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1r0x, resolution 2.20Å

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