1weh: Difference between revisions

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-{{Seed}}
-[[Image:1weh.png|left|200px]]
-<!--
+==Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8==
-The line below this paragraph, containing "STRUCTURE_1weh", creates the "Structure Box" on the page.
+<StructureSection load='1weh' size='340' side='right'caption='[[1weh]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1weh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WEH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_1weh|  PDB=1weh  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1weh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1weh OCA], [https://pdbe.org/1weh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1weh RCSB], [https://www.ebi.ac.uk/pdbsum/1weh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1weh ProSAT], [https://www.topsan.org/Proteins/RSGI/1weh TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5SLJ9_THET8 Q5SLJ9_THET8]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/1weh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1weh ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+TT1887 and TT1465 from Thermus thermophilus HB8 are conserved hypothetical proteins, and are annotated as possible lysine decarboxylases in the Pfam database. Here we report the crystal structures of TT1887 and TT1465 at 1.8 A and 2.2 A resolutions, respectively, as determined by the multiwavelength anomalous dispersion (MAD) method. TT1887 is a homotetramer, while TT1465 is a homohexamer in the crystal and in solution. The structures of the TT1887 and TT1465 monomers contain single domains with the Rossmann fold, comprising six alpha helices and seven beta strands, and are quite similar to each other. The major structural differences exist in the N terminus of TT1465, where there are two additional alpha helices. A comparison of the structures revealed the elements that are responsible for the different oligomerization modes. The distributions of the electrostatic potential on the solvent-accessible surfaces suggested putative active sites.
-===Crystal structure of the conserved hypothetical protein TT1887 from Thermus thermophilus HB8===
+Crystal structures of possible lysine decarboxylases from Thermus thermophilus HB8.,Kukimoto-Niino M, Murayama K, Kato-Murayama M, Idaka M, Bessho Y, Tatsuguchi A, Ushikoshi-Nakayama R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S Protein Sci. 2004 Nov;13(11):3038-42. Epub 2004 Sep 30. PMID:15459330<ref>PMID:15459330</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_15459330}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1weh" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 15459330 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_15459330}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-WEH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WEH OCA].
+[[Category: Thermus thermophilus HB8]]
+[[Category: Idaka M]]
-==Reference==
+[[Category: Kukimoto-Niino M]]
-<ref group="xtra">PMID:15459330</ref><references group="xtra"/>
+[[Category: Kuramitsu S]]
-[[Category: Thermus thermophilus]]
+[[Category: Murayama K]]
-[[Category: Idaka, M.]]
+[[Category: Shirouzu M]]
-[[Category: Kukimoto-Niino, M.]]
+[[Category: Terada T]]
-[[Category: Kuramitsu, S.]]
+[[Category: Yokoyama S]]
-[[Category: Murayama, K.]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Shirouzu, M.]]
-[[Category: Terada, T.]]
-[[Category: Yokoyama, S.]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rossman fold]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:55:53 2009''