2f5i: Difference between revisions

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-{{Seed}}
-[[Image:2f5i.png|left|200px]]
-<!--
+==X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens==
-The line below this paragraph, containing "STRUCTURE_2f5i", creates the "Structure Box" on the page.
+<StructureSection load='2f5i' size='340' side='right'caption='[[2f5i]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2f5i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F5I FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5i OCA], [https://pdbe.org/2f5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f5i RCSB], [https://www.ebi.ac.uk/pdbsum/2f5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f5i ProSAT]</span></td></tr>
-{{STRUCTURE_2f5i|  PDB=2f5i  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN] Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX) [MIM:[https://omim.org/entry/308800 308800]. A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration.<ref>PMID:9341865</ref> <ref>PMID:12215835</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/SAT1_HUMAN SAT1_HUMAN] Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f5/2f5i_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f5i ConSurf].
+<div style="clear:both"></div>
-===X-ray structure of spermidine/spermine N1-acetyltransferase (SAT) from Homo sapiens===
+==See Also==
+*[[Spermidine/spermine N-acetyltransferase|Spermidine/spermine N-acetyltransferase]]
+== References ==
-==About this Structure==
+<references/>
-F5I is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5I OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:16544326</ref><references group="xtra"/>
-[[Category: Diamine N-acetyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Vonrhein, C.]]
+[[Category: Large Structures]]
-[[Category: Wang, D C.]]
+[[Category: Vonrhein C]]
-[[Category: Zhu, D Y.]]
+[[Category: Wang DC]]
-[[Category: Zhu, Y Q.]]
+[[Category: Zhu DY]]
-[[Category: Beta-alpha-barrel]]
+[[Category: Zhu YQ]]
-[[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:21:21 2009''