2fl8: Difference between revisions
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==Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.== | |||
<SX load='2fl8' size='340' side='right' viewer='molstar' caption='[[2fl8]], [[Resolution|resolution]] 12.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2fl8]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FL8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 12Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fl8 OCA], [https://pdbe.org/2fl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fl8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
< | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/2fl8_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
== | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fl8 ConSurf]. | ||
<div style="clear:both"></div> | |||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
[[ | </SX> | ||
[[ | [[Category: Escherichia virus T4]] | ||
[[ | [[Category: Large Structures]] | ||
[ | [[Category: Leiman PG]] | ||
[ | [[Category: Mesyanzhinov VV]] | ||
[[Category: | [[Category: Rossmann MG]] | ||
[[Category: | [[Category: Shneider MM]] | ||
[[Category: | |||
[[Category: | |||
[[Category: | |||
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Latest revision as of 12:24, 14 February 2024
Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.Fitting of the gp10 trimer structure into the cryoEM map of the bacteriophage T4 baseplate in the hexagonal conformation.
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