1oy6: Difference between revisions

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[[Image:1oy6.png|left|200px]]


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==Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump==
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<StructureSection load='1oy6' size='340' side='right'caption='[[1oy6]], [[Resolution|resolution]] 3.68&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1oy6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OY6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.68&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oy6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oy6 OCA], [https://pdbe.org/1oy6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oy6 RCSB], [https://www.ebi.ac.uk/pdbsum/1oy6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oy6 ProSAT]</span></td></tr>
{{STRUCTURE_1oy6|  PDB=1oy6  |  SCENE=  }}
</table>
 
== Function ==
===Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump===
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oy6 ConSurf].
1OY6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY6 OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:12738864</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Jr., D E.Koshland.]]
[[Category: Large Structures]]
[[Category: McDermott, G.]]
[[Category: Koshland Jr DE]]
[[Category: Nikaido, H.]]
[[Category: McDermott G]]
[[Category: Yu, E W.]]
[[Category: Nikaido H]]
[[Category: Zgurskaya, H I.]]
[[Category: Yu EW]]
[[Category: Membrane protein]]
[[Category: Zgurskaya HI]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:51:18 2009''

Latest revision as of 11:03, 14 February 2024

Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux PumpStructural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump

Structural highlights

1oy6 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.68Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACRB_ECOLI AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

1oy6, resolution 3.68Å

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OCA
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