1fkw: Difference between revisions

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-{{Seed}}
-[[Image:1fkw.png|left|200px]]
-<!--
+==MURINE ADENOSINE DEAMINASE (D295E)==
-The line below this paragraph, containing "STRUCTURE_1fkw", creates the "Structure Box" on the page.
+<StructureSection load='1fkw' size='340' side='right'caption='[[1fkw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1fkw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FKW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PUR:PURINE+RIBOSIDE'>PUR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1fkw|  PDB=1fkw  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fkw OCA], [https://pdbe.org/1fkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fkw RCSB], [https://www.ebi.ac.uk/pdbsum/1fkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fkw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/1fkw_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fkw ConSurf].
+<div style="clear:both"></div>
-===MURINE ADENOSINE DEAMINASE (D295E)===
+==See Also==
+*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_8672487}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 8672487 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_8672487}}
-==About this Structure==
-FKW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FKW OCA].
-==Reference==
-<ref group="xtra">PMID:8672487</ref><references group="xtra"/>
-[[Category: Adenosine deaminase]]
 [[Category: Mus musculus]]
-[[Category: Quiocho, F A.]]
+[[Category: Quiocho FA]]
-[[Category: Wilson, D K.]]
+[[Category: Wilson DK]]
-[[Category: Aminohydrolase]]
-[[Category: Tim barrel]]
-[[Category: Zinc cofactor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:27:01 2009''