1oct: Difference between revisions

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-{{Seed}}
-[[Image:1oct.png|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES==
-The line below this paragraph, containing "STRUCTURE_1oct", creates the "Structure Box" on the page.
+<StructureSection load='1oct' size='340' side='right'caption='[[1oct]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1oct]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OCT FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oct OCA], [https://pdbe.org/1oct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oct RCSB], [https://www.ebi.ac.uk/pdbsum/1oct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oct ProSAT]</span></td></tr>
-{{STRUCTURE_1oct|  PDB=1oct  |  SCENE=  }}
+</table>
+== Function ==
-===CRYSTAL STRUCTURE OF THE OCT-1 POU DOMAIN BOUND TO AN OCTAMER SITE: DNA RECOGNITION WITH TETHERED DNA-BINDING MODULES===
+[https://www.uniprot.org/uniprot/PO2F1_HUMAN PO2F1_HUMAN] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:1684878</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_8156594}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 8156594 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/1oct_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_8156594}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oct ConSurf].
-OCT is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCT OCA].
+<div style="clear:both"></div>
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:8156594</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Aurora, R.]]
+[[Category: Large Structures]]
-[[Category: Herr, W.]]
+[[Category: Aurora R]]
-[[Category: Klemm, J D.]]
+[[Category: Herr W]]
-[[Category: Pabo, C O.]]
+[[Category: Klemm JD]]
-[[Category: Rould, M A.]]
+[[Category: Pabo CO]]
-[[Category: Protein-dna complex]]
+[[Category: Rould MA]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:01:00 2009''