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{{Seed}}
[[Image:1rnd.png|left|200px]]


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==NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE==
The line below this paragraph, containing "STRUCTURE_1rnd", creates the "Structure Box" on the page.
<StructureSection load='1rnd' size='340' side='right'caption='[[1rnd]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1rnd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RND FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGP:2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>DGP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1rnd|  PDB=1rnd  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rnd OCA], [https://pdbe.org/1rnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rnd RCSB], [https://www.ebi.ac.uk/pdbsum/1rnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rnd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rn/1rnd_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rnd ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.


===NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE===
Newly observed binding mode in pancreatic ribonuclease.,Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:1548704<ref>PMID:1548704</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1rnd" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_1548704}}, adds the Publication Abstract to the page
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 1548704 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_1548704}}
__TOC__
 
</StructureSection>
==About this Structure==
1RND is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA].
 
==Reference==
<ref group="xtra">PMID:1548704</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Pancreatic ribonuclease]]
[[Category: Large Structures]]
[[Category: Aguilar, C F.]]
[[Category: Aguilar CF]]
[[Category: Mills, A.]]
[[Category: Mills A]]
[[Category: Moss, D S.]]
[[Category: Moss DS]]
[[Category: Palmer, R A.]]
[[Category: Palmer RA]]
[[Category: Thomas, P J.]]
[[Category: Thomas PJ]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:26:28 2009''

Latest revision as of 07:51, 17 October 2024

NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASENEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE

Structural highlights

1rnd is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RNAS1_BOVIN Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.

Newly observed binding mode in pancreatic ribonuclease.,Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:1548704[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ delCardayre SB, Ribo M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Eng. 1995 Mar;8(3):261-73. PMID:7479688
  2. ↑ Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA. Newly observed binding mode in pancreatic ribonuclease. J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:1548704

1rnd, resolution 1.50Å

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