1kxu: Difference between revisions

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-{{Seed}}
-[[Image:1kxu.png|left|200px]]
-<!--
+==CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE==
-The line below this paragraph, containing "STRUCTURE_1kxu", creates the "Structure Box" on the page.
+<StructureSection load='1kxu' size='340' side='right'caption='[[1kxu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1kxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXU FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxu OCA], [https://pdbe.org/1kxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxu RCSB], [https://www.ebi.ac.uk/pdbsum/1kxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxu ProSAT]</span></td></tr>
-{{STRUCTURE_1kxu|  PDB=1kxu  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CCNH_HUMAN CCNH_HUMAN] Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.<ref>PMID:7533895</ref> <ref>PMID:10024882</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kx/1kxu_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kxu ConSurf].
+<div style="clear:both"></div>
-===CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE===
+==See Also==
+*[[Cyclin 3D structures|Cyclin 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_8836101}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 8836101 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_8836101}}
-==About this Structure==
-KXU is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXU OCA].
-==Reference==
-<ref group="xtra">PMID:8836101</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chamberin, H M.]]
+[[Category: Large Structures]]
-[[Category: Kim, K K.]]
+[[Category: Chamberin HM]]
-[[Category: Kim, S H.]]
+[[Category: Kim KK]]
-[[Category: Morgan, D O.]]
+[[Category: Kim S-H]]
-[[Category: Alpha-helical structure]]
+[[Category: Morgan DO]]
-[[Category: Cell cycle]]
-[[Category: Cell division]]
-[[Category: Cyclin]]
-[[Category: Nuclear protein]]
-[[Category: Regulatory protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 02:23:20 2009''