3e3t: Difference between revisions

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-{{Seed}}
-[[Image:3e3t.png|left|200px]]
-<!--
+==Structure of porcine pancreatic elastase with the magic triangle I3C==
-The line below this paragraph, containing "STRUCTURE_3e3t", creates the "Structure Box" on the page.
+<StructureSection load='3e3t' size='340' side='right'caption='[[3e3t]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3e3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E3T FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3C:5-AMINO-2,4,6-TRIIODOBENZENE-1,3-DICARBOXYLIC+ACID'>I3C</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3e3t|  PDB=3e3t  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3t OCA], [https://pdbe.org/3e3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e3t RCSB], [https://www.ebi.ac.uk/pdbsum/3e3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e3t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e3/3e3t_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e3t ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Obtaining phase information for the solution of macromolecular structures is still one of the bottlenecks in X-ray crystallography. 5-Amino-2,4,6-triiodoisophthalic acid (I3C), in which three covalently bound iodines form an equilateral triangle, was incorporated into proteins in order to obtain phases by single-wavelength anomalous dispersion (SAD). An improved binding capability compared with simple heavy-metal ions, ready availability, improved recognition of potential heavy-atom sites and low toxicity make I3C particularly suitable for experimental phasing.
-===Structure of porcine pancreatic elastase with the magic triangle I3C===
+A magic triangle for experimental phasing of macromolecules.,Beck T, Krasauskas A, Gruene T, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 2008 Nov;64(Pt 11):1179-82. Epub 2008, Oct 18. PMID:19020357<ref>PMID:19020357</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3e3t" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-E3T is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E3T OCA].
+*[[Elastase 3D structures|Elastase 3D structures]]
-[[Category: Pancreatic elastase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Sus scrofa]]
-[[Category: Beck, T.]]
+[[Category: Beck T]]
-[[Category: Gruene, T.]]
+[[Category: Gruene T]]
-[[Category: Sheldrick, G M.]]
+[[Category: Sheldrick GM]]
-[[Category: 5-amino-2]]
-[[Category: 6-triiodoisophthalic acid]]
-[[Category: Calcium]]
-[[Category: Hydrolase]]
-[[Category: I3c]]
-[[Category: Magic triangle]]
-[[Category: Metal-binding]]
-[[Category: Phasing tool]]
-[[Category: Protease]]
-[[Category: Secreted]]
-[[Category: Serine protease]]
-[[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:06:24 2009''