2bel: Difference between revisions

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-{{Seed}}
-[[Image:2bel.png|left|200px]]
-<!--
+==Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone==
-The line below this paragraph, containing "STRUCTURE_2bel", creates the "Structure Box" on the page.
+<StructureSection load='2bel' size='340' side='right'caption='[[2bel]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2bel]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BEL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBO:CARBENOXOLONE'>CBO</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-{{STRUCTURE_2bel|  PDB=2bel  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bel OCA], [https://pdbe.org/2bel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bel RCSB], [https://www.ebi.ac.uk/pdbsum/2bel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bel ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
+== Function ==
+[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/2bel_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bel ConSurf].
+<div style="clear:both"></div>
-===STRUCTURE OF HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH NADP AND CARBENOXOLONE===
+==See Also==
+*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-BEL is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BEL OCA].
-[[Category: 11-beta-hydroxysteroid dehydrogenase]]
 [[Category: Homo sapiens]]
-[[Category: Abrahmsen, L.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C.]]
+[[Category: Abrahmsen L]]
-[[Category: Bray, J.]]
+[[Category: Arrowsmith C]]
-[[Category: Debreczeni, J E.]]
+[[Category: Bray J]]
-[[Category: Delft, F Von.]]
+[[Category: Debreczeni JE]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Elleby, B.]]
+[[Category: Elleby B]]
-[[Category: Kavanagh, K.]]
+[[Category: Kavanagh K]]
-[[Category: Oppermann, U.]]
+[[Category: Oppermann U]]
-[[Category: Sharma, S.]]
+[[Category: Sharma S]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Svensson, S.]]
+[[Category: Svensson S]]
-[[Category: Wu, X.]]
+[[Category: Wu X]]
-[[Category: Drug target]]
+[[Category: Von Delft F]]
-[[Category: Glucocorticoid activation]]
-[[Category: Hormone metabolism]]
-[[Category: Inhibitor]]
-[[Category: Microsome]]
-[[Category: Nadp]]
-[[Category: Oxidoreductase]]
-[[Category: Short-chain dehydrogenase/reductase]]
-[[Category: Steroid metabolism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:45:29 2009''