1jkx: Difference between revisions

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{{Seed}}
[[Image:1jkx.png|left|200px]]


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==Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase==
The line below this paragraph, containing "STRUCTURE_1jkx", creates the "Structure Box" on the page.
<StructureSection load='1jkx' size='340' side='right'caption='[[1jkx]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1jkx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JKX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=138:N-[5-O-PHOSPHONO-RIBOFURANOSYL]-2-[2-HYDROXY-2-[4-[GLUTAMIC+ACID]-N-CARBONYLPHENYL]-3-[2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL]-PROPANYLAMINO]-ACETAMIDE'>138</scene></td></tr>
{{STRUCTURE_1jkx|  PDB=1jkx  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jkx OCA], [https://pdbe.org/1jkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jkx RCSB], [https://www.ebi.ac.uk/pdbsum/1jkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jkx ProSAT]</span></td></tr>
 
</table>
===Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase===
== Function ==
 
[https://www.uniprot.org/uniprot/PUR3_ECOLI PUR3_ECOLI]
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_11695901}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 11695901 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jkx_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_11695901}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
1JKX is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JKX OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jkx ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:11695901</ref><references group="xtra"/>
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Phosphoribosylglycinamide formyltransferase]]
[[Category: Large Structures]]
[[Category: Baker, S.]]
[[Category: Baker S]]
[[Category: Benkovic, S J.]]
[[Category: Benkovic SJ]]
[[Category: Boger, D L.]]
[[Category: Boger DL]]
[[Category: Cai, H.]]
[[Category: Cai H]]
[[Category: Greasley, S E.]]
[[Category: Greasley SE]]
[[Category: Marsilje, T H.]]
[[Category: Marsilje TH]]
[[Category: Wilson, I A.]]
[[Category: Wilson IA]]
[[Category: Anti-cancer agent]]
[[Category: Enzyme-assembled multisubstrate adduct inhibitor complex]]
[[Category: Purine biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:38:07 2009''

Latest revision as of 16:24, 13 March 2024

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylaseUnexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase

Structural highlights

1jkx is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PUR3_ECOLI

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1jkx, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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