2h9m: Difference between revisions

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-{{Seed}}
-[[Image:2h9m.png|left|200px]]
-<!--
+==WDR5 in complex with unmodified H3K4 peptide==
-The line below this paragraph, containing "STRUCTURE_2h9m", creates the "Structure Box" on the page.
+<StructureSection load='2h9m' size='340' side='right'caption='[[2h9m]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2h9m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H9M FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h9m OCA], [https://pdbe.org/2h9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h9m RCSB], [https://www.ebi.ac.uk/pdbsum/2h9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h9m ProSAT]</span></td></tr>
-{{STRUCTURE_2h9m|  PDB=2h9m  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/2h9m_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h9m ConSurf].
+<div style="clear:both"></div>
-===WDR5 in complex with unmodified H3K4 peptide===
+==See Also==
+*[[WD repeat-containing protein|WD repeat-containing protein]]
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_16946699}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 16946699 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_16946699}}
-==About this Structure==
-H9M is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9M OCA].
-==Reference==
-<ref group="xtra">PMID:16946699</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Allali-Hassani, A.]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Xenopus tropicalis]]
-[[Category: Bochkarev, A.]]
+[[Category: Allali-Hassani A]]
-[[Category: Edwards, A M.]]
+[[Category: Arrowsmith CH]]
-[[Category: Loppnau, P.]]
+[[Category: Bochkarev A]]
-[[Category: Martin, F.]]
+[[Category: Edwards AM]]
-[[Category: Min, J R.]]
+[[Category: Loppnau P]]
-[[Category: Plotnikov, A N.]]
+[[Category: Martin F]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Min JR]]
-[[Category: Schuetz, A.]]
+[[Category: Plotnikov AN]]
-[[Category: Sundstrom, M.]]
+[[Category: Schuetz A]]
-[[Category: Vedadi, M.]]
+[[Category: Sundstrom M]]
-[[Category: Weigelt, J.]]
+[[Category: Vedadi M]]
-[[Category: Sgc]]
+[[Category: Weigelt J]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Wdr5]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:27:42 2009''

2h9m: Difference between revisions

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