1tqn: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:1tqn.png|left|200px]]
-<!--
+==Crystal Structure of Human Microsomal P450 3A4==
-The line below this paragraph, containing "STRUCTURE_1tqn", creates the "Structure Box" on the page.
+<StructureSection load='1tqn' size='340' side='right'caption='[[1tqn]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1tqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TQN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-{{STRUCTURE_1tqn|  PDB=1tqn  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tqn OCA], [https://pdbe.org/1tqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tqn RCSB], [https://www.ebi.ac.uk/pdbsum/1tqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tqn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CP3A4_HUMAN CP3A4_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.<ref>PMID:11159812</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tq/1tqn_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tqn ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Human Microsomal P450 3A4===
+==See Also==
+*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_15258162}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 15258162 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_15258162}}
-==About this Structure==
-TQN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TQN OCA].
-==Reference==
-<ref group="xtra">PMID:15258162</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Unspecific monooxygenase]]
+[[Category: Large Structures]]
-[[Category: Griffin, K J.]]
+[[Category: Griffin KJ]]
-[[Category: Johnson, E F.]]
+[[Category: Johnson EF]]
-[[Category: Schoch, G A.]]
+[[Category: Schoch GA]]
-[[Category: Stout, C D.]]
+[[Category: Stout CD]]
-[[Category: Wester, M R.]]
+[[Category: Wester MR]]
-[[Category: Yano, J K.]]
+[[Category: Yano JK]]
-[[Category: Cyp3a4]]
-[[Category: Drug metabolizing enzyme]]
-[[Category: Heme]]
-[[Category: Monooxygenase]]
-[[Category: Oxidoreductase]]
-[[Category: P450]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:38:18 2009''