1kaz: Difference between revisions

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{{Seed}}
[[Image:1kaz.png|left|200px]]


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==70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT==
The line below this paragraph, containing "STRUCTURE_1kaz", creates the "Structure Box" on the page.
<StructureSection load='1kaz' size='340' side='right'caption='[[1kaz]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1kaz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KAZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1kaz| PDB=1kaz |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kaz OCA], [https://pdbe.org/1kaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kaz RCSB], [https://www.ebi.ac.uk/pdbsum/1kaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kaz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/1kaz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kaz ConSurf].
<div style="clear:both"></div>


===70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_8663302}}
 
==About this Structure==
1KAZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KAZ OCA].
 
==Reference==
<ref group="xtra">PMID:8663302</ref><references group="xtra"/>
[[Category: Adenosinetriphosphatase]]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Brien, M C.O.]]
[[Category: Large Structures]]
[[Category: Flaherty, K M.]]
[[Category: Flaherty KM]]
[[Category: Mckay, D B.]]
[[Category: Mckay DB]]
[[Category: Atp-binding]]
[[Category: O'Brien MC]]
[[Category: Heat shock]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:57:32 2009''

Latest revision as of 10:45, 7 February 2024

70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT70KD HEAT SHOCK COGNATE PROTEIN ATPASE DOMAIN, K71E MUTANT

Structural highlights

1kaz is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HSP7C_BOVIN Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1kaz, resolution 1.70Å

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