2cbu: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2cbu.gif|left|200px]]<br />
-<applet load="2cbu" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2cbu, resolution 1.85&Aring;" />
-'''BETA-GLUCOSIDASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH CASTANOSPERMINE'''<br />
-==About this Structure==
+==Beta-glucosidase from Thermotoga maritima in complex with castanospermine==
-CBU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ACT, CA and CTS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA]].
+<StructureSection load='2cbu' size='340' side='right'caption='[[2cbu]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2cbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CBU FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CTS:CASTANOSPERMINE'>CTS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cbu OCA], [https://pdbe.org/2cbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cbu RCSB], [https://www.ebi.ac.uk/pdbsum/2cbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cbu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cb/2cbu_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cbu ConSurf].
+<div style="clear:both"></div>
-==Reference==
+==See Also==
-Dissection of conformationally restricted inhibitors binding to a beta-glucosidase., Gloster TM, Madsen R, Davies GJ, Chembiochem. 2006 May;7(5):738-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16628756 16628756]
+*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]]
-[[Category: Single protein]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Thermotoga maritima]]
-[[Category: Davies, G.J.]]
+[[Category: Davies GJ]]
-[[Category: Gloster, T.M.]]
+[[Category: Gloster TM]]
-[[Category: Madsen, R.]]
+[[Category: Madsen R]]
-[[Category: ACT]]
-[[Category: CA]]
-[[Category: CTS]]
-[[Category: carbohydrate metabolism]]
-[[Category: cellulose degradation]]
-[[Category: family 1]]
-[[Category: glycosidase]]
-[[Category: glycoside hydrolase]]
-[[Category: hydrolase]]
-[[Category: inhibitor]]
-[[Category: polysaccharide degradation]]
-[[Category: transition state mimic]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 21:25:16 2007''