1wpw: Difference between revisions

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New page: left|200px<br /><applet load="1wpw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1wpw, resolution 2.80Å" /> '''Crystal Structure of...
 
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[[Image:1wpw.jpg|left|200px]]<br /><applet load="1wpw" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1wpw, resolution 2.80&Aring;" />
'''Crystal Structure of IPMDH from Sulfolobus tokodaii'''<br />


==About this Structure==
==Crystal Structure of IPMDH from Sulfolobus tokodaii==
1WPW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_tokodaii Sulfolobus tokodaii] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WPW OCA].
<StructureSection load='1wpw' size='340' side='right'caption='[[1wpw]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
[[Category: 3-isopropylmalate dehydrogenase]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[1wpw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPW FirstGlance]. <br>
[[Category: Sulfolobus tokodaii]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
[[Category: Hirose, R.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Moriyama, H.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpw OCA], [https://pdbe.org/1wpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpw RCSB], [https://www.ebi.ac.uk/pdbsum/1wpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpw ProSAT]</span></td></tr>
[[Category: Oshima, T.]]
</table>
[[Category: Sakurai, M.]]
== Function ==
[[Category: Sato, T.]]
[https://www.uniprot.org/uniprot/LEU3_SULTO LEU3_SULTO] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
[[Category: Suzuki, T.]]
== Evolutionary Conservation ==
[[Category: Tanaka, N.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Yamagishi, A.]]
Check<jmol>
[[Category: MG]]
  <jmolCheckbox>
[[Category: oxidoreductase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpw_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wpw ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:35:45 2007''
==See Also==
*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Sulfurisphaera tokodaii]]
[[Category: Hirose R]]
[[Category: Moriyama H]]
[[Category: Oshima T]]
[[Category: Sakurai M]]
[[Category: Sato T]]
[[Category: Suzuki T]]
[[Category: Tanaka N]]
[[Category: Yamagishi A]]

Latest revision as of 10:29, 9 October 2024

Crystal Structure of IPMDH from Sulfolobus tokodaiiCrystal Structure of IPMDH from Sulfolobus tokodaii

Structural highlights

1wpw is a 2 chain structure with sequence from Sulfurisphaera tokodaii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LEU3_SULTO Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1wpw, resolution 2.80Å

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