3e6t: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3e6t.png|left|200px]]
-<!--
+==Structure of murine INOS oxygenase domain with inhibitor AR-C118901==
-The line below this paragraph, containing "STRUCTURE_3e6t", creates the "Structure Box" on the page.
+<StructureSection load='3e6t' size='340' side='right'caption='[[3e6t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3e6t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E6T FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1A2:5-(4-AMINO-1-ETHYL-5,8-DIFLUORO-1H-SPIRO[PIPERIDINE-4,2-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE'>1A2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-{{STRUCTURE_3e6t|  PDB=3e6t  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e6t OCA], [https://pdbe.org/3e6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e6t RCSB], [https://www.ebi.ac.uk/pdbsum/3e6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e6t ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e6/3e6t_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e6t ConSurf].
+<div style="clear:both"></div>
-===Structure of murine INOS oxygenase domain with inhibitor AR-C118901===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18849972}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18849972 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_18849972}}
-==About this Structure==
-E6T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E6T OCA].
-==Reference==
-Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase., Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED, Nat Chem Biol. 2008 Nov;4(11):700-7. Epub 2008 Oct 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18849972 18849972]
 [[Category: Mus musculus]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Aberg A]]
-[[Category: Single protein]]
+[[Category: Andersson G]]
-[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
+[[Category: Andrews G]]
-[[Category: Calmodulin-binding]]
+[[Category: Arvai AS]]
-[[Category: Fad]]
+[[Category: Cheshire DR]]
-[[Category: Fmn]]
+[[Category: Connolly S]]
-[[Category: Heme]]
+[[Category: Crane BR]]
-[[Category: Iron]]
+[[Category: Garcin ED]]
-[[Category: Metal-binding]]
+[[Category: Gensmantel NP]]
-[[Category: Nadp]]
+[[Category: Getzoff ED]]
-[[Category: Nitric oxide]]
+[[Category: Hamley PJ]]
-[[Category: No]]
+[[Category: Kroeger MD]]
-[[Category: Oxidoreductase]]
+[[Category: Mallinder PR]]
-[[Category: Polymorphism]]
+[[Category: Mete A]]
-[[Category: Tetrahydrobiopterin]]
+[[Category: Nicholls DJ]]
-[[Category: Zinc]]
+[[Category: Rosenfeld RJ]]
+[[Category: St-Gallay SA]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 20:20:49 2009''
+[[Category: Stueh DJ]]
+[[Category: Tainer JA]]
+[[Category: Tinker AC]]
+[[Category: Wallace AV]]