3fbi: Difference between revisions

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-{{Seed}}
-[[Image:3fbi.jpg|left|200px]]
-<!--
+==Structure of the Mediator submodule Med7N/31==
-The line below this paragraph, containing "STRUCTURE_3fbi", creates the "Structure Box" on the page.
+<StructureSection load='3fbi' size='340' side='right'caption='[[3fbi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3fbi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_3fbi|  PDB=3fbi  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbi OCA], [https://pdbe.org/3fbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbi RCSB], [https://www.ebi.ac.uk/pdbsum/3fbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MED7_YEAST MED7_YEAST] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.<ref>PMID:11555651</ref> <ref>PMID:16076843</ref> <ref>PMID:16263706</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Mediator is a modular multiprotein complex required for regulated transcription by RNA polymerase (Pol) II. Here, we show that the middle module of the Mediator core contains a submodule of unique structure and function that comprises the N-terminal part of subunit Med7 (Med7N) and the highly conserved subunit Med31 (Soh1). The Med7N/31 submodule shows a conserved novel fold, with two proline-rich stretches in Med7N wrapping around the right-handed four-helix bundle of Med31. In vitro, Med7N/31 is required for activated transcription and can act in trans when added exogenously. In vivo, Med7N/31 has a predominantly positive function on the expression of a specific subset of genes, including genes involved in methionine metabolism and iron transport. Comparative phenotyping and transcriptome profiling identify specific and overlapping functions of different Mediator submodules.
-===Structure of the Mediator submodule Med7N/31===
+Identification, structure, and functional requirement of the Mediator submodule Med7N/31.,Koschubs T, Seizl M, Lariviere L, Kurth F, Baumli S, Martin DE, Cramer P EMBO J. 2009 Jan 7;28(1):69-80. Epub 2008 Dec 4. PMID:19057509<ref>PMID:19057509</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3fbi" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19057509}}, adds the Publication Abstract to the page
+*[[Mediator|Mediator]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19057509 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19057509}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-FBI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBI OCA].
-==Reference==
-Identification, structure, and functional requirement of the Mediator submodule Med7N/31., Koschubs T, Seizl M, Lariviere L, Kurth F, Baumli S, Martin DE, Cramer P, EMBO J. 2008 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19057509 19057509]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Baumli, S.]]
+[[Category: Baumli S]]
-[[Category: Cramer, P.]]
+[[Category: Cramer P]]
-[[Category: Koschubs, T.]]
+[[Category: Koschubs T]]
-[[Category: Kurth, F.]]
+[[Category: Kurth F]]
-[[Category: Lariviere, L.]]
+[[Category: Lariviere L]]
-[[Category: Martin, D E.]]
+[[Category: Martin DE]]
-[[Category: Seizl, M.]]
+[[Category: Seizl M]]
-[[Category: Activator]]
-[[Category: Nucleus]]
-[[Category: Proline-rich stretch]]
-[[Category: Protein-protein complex]]
-[[Category: Right-handed four-helix bundle]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 17 13:47:37 2008''