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[[Image:3exc.png|left|200px]]


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==Structure of the RNA'se SSO8090 from Sulfolobus solfataricus==
The line below this paragraph, containing "STRUCTURE_3exc", creates the "Structure Box" on the page.
<StructureSection load='3exc' size='340' side='right'caption='[[3exc]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3exc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EXC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
{{STRUCTURE_3exc|  PDB=3exc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3exc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3exc OCA], [https://pdbe.org/3exc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3exc RCSB], [https://www.ebi.ac.uk/pdbsum/3exc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3exc ProSAT], [https://www.topsan.org/Proteins/MCSG/3exc TOPSAN]</span></td></tr>
 
</table>
===Structure of the RNA'se SSO8090 from Sulfolobus solfataricus===
== Function ==
 
[https://www.uniprot.org/uniprot/CAS2B_SACS2 CAS2B_SACS2] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).<ref>PMID:18482976</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3EXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EXC OCA].  
Check<jmol>
[[Category: Single protein]]
  <jmolCheckbox>
[[Category: Sulfolobus solfataricus]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/3exc_consurf.spt"</scriptWhenChecked>
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Catalytic aspartate]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Dimer]]
  </jmolCheckbox>
[[Category: Double split beta-alpha-beta fold]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3exc ConSurf].
[[Category: Ferredoxin fold]]
<div style="clear:both"></div>
[[Category: Hydrolase]]
== References ==
[[Category: Mcsg]]
<references/>
[[Category: Midwest center for structural genomic]]
__TOC__
[[Category: Protein structure initiative]]
</StructureSection>
[[Category: Psi-2]]
[[Category: Large Structures]]
[[Category: Rna'ase]]
[[Category: Saccharolobus solfataricus]]
 
[[Category: Edwards AM]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 20:26:47 2008''
[[Category: Joachimiak A]]
[[Category: Kagan O]]
[[Category: Onopriyenko O]]
[[Category: Savchenko A]]
[[Category: Singer AU]]
[[Category: Skarina T]]
[[Category: Tan K]]
[[Category: Yakunin AF]]

Latest revision as of 04:47, 21 November 2024

Structure of the RNA'se SSO8090 from Sulfolobus solfataricusStructure of the RNA'se SSO8090 from Sulfolobus solfataricus

Structural highlights

3exc is a 1 chain structure with sequence from Saccharolobus solfataricus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.25Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CAS2B_SACS2 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette (By similarity).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF. A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. J Biol Chem. 2008 Jul 18;283(29):20361-71. Epub 2008 May 15. PMID:18482976 doi:10.1074/jbc.M803225200

3exc, resolution 2.25Å

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