2ae3: Difference between revisions

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[[Image:2ae3.png|left|200px]]


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==Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism==
The line below this paragraph, containing "STRUCTURE_2ae3", creates the "Structure Box" on the page.
<StructureSection load='2ae3' size='340' side='right'caption='[[2ae3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ae3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp._GK16 Pseudomonas sp. GK16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AE3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2ae3| PDB=2ae3 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ae3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ae3 OCA], [https://pdbe.org/2ae3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ae3 RCSB], [https://www.ebi.ac.uk/pdbsum/2ae3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ae3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2ae3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ae3 ConSurf].
<div style="clear:both"></div>


===Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism===
==See Also==
 
*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 16446446 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_16446446}}
[[Category: Pseudomonas sp. GK16]]
 
[[Category: Cho KJ]]
==About this Structure==
[[Category: Kim JK]]
2AE3 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_sp._gk16 Pseudomonas sp. gk16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AE3 OCA].
[[Category: Kim KH]]
 
[[Category: Kim SH]]
==Reference==
[[Category: Park SS]]
Insight into autoproteolytic activation from the structure of cephalosporin acylase: a protein with two proteolytic chemistries., Kim JK, Yang IS, Shin HJ, Cho KJ, Ryu EK, Kim SH, Park SS, Kim KH, Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1732-7. Epub 2006 Jan 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16446446 16446446]
[[Category: Ryu EK]]
[[Category: Penicillin amidase]]
[[Category: Shin HJ]]
[[Category: Protein complex]]
[[Category: Yang IS]]
[[Category: Pseudomonas sp. gk16]]
[[Category: Cho, K J.]]
[[Category: Kim, J K.]]
[[Category: Kim, K H.]]
[[Category: Kim, S H.]]
[[Category: Park, S S.]]
[[Category: Ryu, E K.]]
[[Category: Shin, H J.]]
[[Category: Yang, I S.]]
[[Category: Autoproteolysis]]
[[Category: Cephalosporin acylase]]
[[Category: Hydrolase]]
[[Category: Intermediate structure]]
[[Category: Precursor activation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 26 20:33:42 2008''

Latest revision as of 16:40, 13 March 2024

Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanismGlutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism

Structural highlights

2ae3 is a 2 chain structure with sequence from Pseudomonas sp. GK16. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

G7AC_PSEU7 Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Matsuda A, Komatsu KI. Molecular cloning and structure of the gene for 7 beta-(4-carboxybutanamido)cephalosporanic acid acylase from a Pseudomonas strain. J Bacteriol. 1985 Sep;163(3):1222-8. PMID:2993240

2ae3, resolution 2.40Å

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