3c96: Difference between revisions

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[[Image:3c96.png|left|200px]]


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==Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR240==
The line below this paragraph, containing "STRUCTURE_3c96", creates the "Structure Box" on the page.
<StructureSection load='3c96' size='340' side='right'caption='[[3c96]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C96 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
{{STRUCTURE_3c96| PDB=3c96 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c96 OCA], [https://pdbe.org/3c96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c96 RCSB], [https://www.ebi.ac.uk/pdbsum/3c96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c96 ProSAT], [https://www.topsan.org/Proteins/NESGC/3c96 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHZS_PSEAE PHZS_PSEAE] Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Catalyzes the oxidative decarboxylation of 5-methylphenazine-1-carboxylate (5-methyl-PCA) to pyocyanine. Can also act on phenazine-1-carboxylate (PCA), converting it into 1-hydroxyphenazine (1-HP). However, PCA is a poor substrate.<ref>PMID:17253782</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/3c96_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c96 ConSurf].
<div style="clear:both"></div>


===Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR240===
==See Also==
 
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
 
== References ==
==About this Structure==
<references/>
3C96 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_pao1 Pseudomonas aeruginosa pao1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C96 OCA].
__TOC__
[[Category: Pseudomonas aeruginosa pao1]]
</StructureSection>
[[Category: Acton, T B.]]
[[Category: Large Structures]]
[[Category: Chen, Y.]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Hunt, J F.]]
[[Category: Acton TB]]
[[Category: Mao, L.]]
[[Category: Chen Y]]
[[Category: Montelione, G T.]]
[[Category: Hunt JF]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Mao L]]
[[Category: Seetharaman, J.]]
[[Category: Montelione GT]]
[[Category: Tong, L.]]
[[Category: Seetharaman J]]
[[Category: Vorobiev, S M.]]
[[Category: Tong L]]
[[Category: Wang, D.]]
[[Category: Vorobiev SM]]
[[Category: Xiao, R.]]
[[Category: Wang D]]
[[Category: Fad]]
[[Category: Xiao R]]
[[Category: Monooxygenase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Oxidoreductase]]
[[Category: Par240]]
[[Category: Pf01266]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 18:52:52 2008''

Latest revision as of 12:33, 21 February 2024

Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR240Crystal structure of the flavin-containing monooxygenase phzS from Pseudomonas aeruginosa. Northeast Structural Genomics Consortium target PaR240

Structural highlights

3c96 is a 1 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

PHZS_PSEAE Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Catalyzes the oxidative decarboxylation of 5-methylphenazine-1-carboxylate (5-methyl-PCA) to pyocyanine. Can also act on phenazine-1-carboxylate (PCA), converting it into 1-hydroxyphenazine (1-HP). However, PCA is a poor substrate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Parsons JF, Greenhagen BT, Shi K, Calabrese K, Robinson H, Ladner JE. Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Biochemistry. 2007 Feb 20;46(7):1821-8. Epub 2007 Jan 25. PMID:17253782 doi:10.1021/bi6024403

3c96, resolution 1.90Å

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