2ecl: Difference between revisions

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-{{Seed}}
-[[Image:2ecl.png|left|200px]]
-<!--
+==Solution Structure of the RING domain of the human RING-box protein 2==
-The line below this paragraph, containing "STRUCTURE_2ecl", creates the "Structure Box" on the page.
+<StructureSection load='2ecl' size='340' side='right'caption='[[2ecl]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ecl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ECL FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2ecl|  PDB=2ecl  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ecl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ecl OCA], [https://pdbe.org/2ecl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ecl RCSB], [https://www.ebi.ac.uk/pdbsum/2ecl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ecl ProSAT], [https://www.topsan.org/Proteins/RSGI/2ecl TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RBX2_HUMAN RBX2_HUMAN] Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.<ref>PMID:10851089</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ecl_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ecl ConSurf].
+<div style="clear:both"></div>
-===Solution Structure of the RING domain of the human RING-box protein 2===
+==See Also==
+*[[Ring box protein 3D structures|Ring box protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-ECL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ECL OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Harada, T.]]
+[[Category: Large Structures]]
-[[Category: Kigawa, T.]]
+[[Category: Harada T]]
-[[Category: Koshiba, S.]]
+[[Category: Kigawa T]]
-[[Category: Miyamoto, K.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Miyamoto K]]
-[[Category: Tomizawa, T.]]
+[[Category: Tomizawa T]]
-[[Category: Watanabe, S.]]
+[[Category: Watanabe S]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Metal binding protein]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Ring domian]]
-[[Category: Ring-box protein 2]]
-[[Category: Rnf7]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Zinc-binding domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 17:13:07 2008''