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< | ==Solution structure of the C-terminal RNA binding domain in Heterogeneous nuclear ribonucleoprotein M== | ||
<StructureSection load='2dh9' size='340' side='right'caption='[[2dh9]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2dh9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DH9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dh9 OCA], [https://pdbe.org/2dh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dh9 RCSB], [https://www.ebi.ac.uk/pdbsum/2dh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dh9 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dh9 TOPSAN]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HNRPM_HUMAN HNRPM_HUMAN] Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dh9_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dh9 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Inoue | [[Category: Large Structures]] | ||
[[Category: Kigawa | [[Category: Inoue M]] | ||
[[Category: Muto | [[Category: Kigawa T]] | ||
[[Category: Ochi | [[Category: Muto Y]] | ||
[[Category: Ochi T]] | |||
[[Category: Shirouzu | [[Category: Shirouzu M]] | ||
[[Category: Terada | [[Category: Terada T]] | ||
[[Category: Tsuda | [[Category: Tsuda K]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 14:38, 22 May 2024
Solution structure of the C-terminal RNA binding domain in Heterogeneous nuclear ribonucleoprotein MSolution structure of the C-terminal RNA binding domain in Heterogeneous nuclear ribonucleoprotein M
Structural highlights
FunctionHNRPM_HUMAN Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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