1ys7: Difference between revisions

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-{{Seed}}
-[[Image:1ys7.png|left|200px]]
-<!--
+==Crystal structure of the response regulator protein prrA complexed with Mg2+==
-The line below this paragraph, containing "STRUCTURE_1ys7", creates the "Structure Box" on the page.
+<StructureSection load='1ys7' size='340' side='right'caption='[[1ys7]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ys7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YS7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-{{STRUCTURE_1ys7|  PDB=1ys7  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ys7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ys7 OCA], [https://pdbe.org/1ys7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ys7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ys7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ys7 ProSAT], [https://www.topsan.org/Proteins/XMTB/1ys7 TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRRA_MYCTU PRRA_MYCTU] Member of the two-component regulatory system PrrB/PrrA. Involved specifically in early intracellular multiplication of Mycobacterium.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ys/1ys7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ys7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The structure of the two-domain response regulator PrrA from Mycobacterium tuberculosis shows a compact structure in the crystal with a well defined interdomain interface. The interface, which does not include the interdomain linker, makes the recognition helix and the trans-activation loop of the effector domain inaccessible for interaction with DNA. Part of the interface involves hydrogen-bonding interactions of a tyrosine residue in the receiver domain that is believed to be involved in signal transduction, which, if disrupted, would destabilize the interdomain interface, allowing a more extended conformation of the molecule, which would in turn allow access to the recognition helix. In solution, there is evidence for an equilibrium between compact and extended forms of the protein that is far toward the compact form when the protein is inactivated but moves toward a more extended form when activated by the cognate sensor kinase PrrB.
-===Crystal structure of the response regulator protein prrA comlexed with Mg2+===
+The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis.,Nowak E, Panjikar S, Konarev P, Svergun DI, Tucker PA J Biol Chem. 2006 Apr 7;281(14):9659-66. Epub 2006 Jan 23. PMID:16434396<ref>PMID:16434396</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1ys7" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-YS7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YS7 OCA].
+*[[Response regulator 3D structure|Response regulator 3D structure]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Nowak, E.]]
+[[Category: Nowak E]]
-[[Category: Panjikar, S.]]
+[[Category: Panjikar S]]
-[[Category: Tucker, P.]]
+[[Category: Tucker P]]
-[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
-[[Category: Dna binding domain]]
-[[Category: Mycobacterium tuberculosis structural proteomics project]]
-[[Category: Phosphorylation]]
-[[Category: Response regulator]]
-[[Category: Structural genomic]]
-[[Category: Xmtb]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 14:19:37 2008''