2z0a: Difference between revisions

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-{{Seed}}
-[[Image:2z0a.png|left|200px]]
-<!--
+==Crystal structure of RNA-binding domain of NS1 from influenza A virus A/crow/Kyoto/T1/2004(H5N1)==
-The line below this paragraph, containing "STRUCTURE_2z0a", creates the "Structure Box" on the page.
+<StructureSection load='2z0a' size='340' side='right'caption='[[2z0a]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2z0a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z0A FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
-{{STRUCTURE_2z0a|  PDB=2z0a  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z0a OCA], [https://pdbe.org/2z0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z0a RCSB], [https://www.ebi.ac.uk/pdbsum/2z0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z0a ProSAT], [https://www.topsan.org/Proteins/RSGI/2z0a TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q5H7J4_9INFA Q5H7J4_9INFA] Inhibits post-transcriptional processing of cellular pre-mRNA, by binding and inhibiting two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs: the 30 kDa cleavage and polyadenylation specificity factor/CPSF4 and the poly(A)-binding protein 2/PABPN1. In turn, unprocessed 3' end pre-mRNAs accumulate in the host nucleus and are no longer exported to the cytoplasm. Cellular protein synthesis is thereby shut off very early after virus infection. Viral protein synthesis is not affected by the inhibition of the cellular 3' end processing machinery because the poly(A) tails of viral mRNAs are produced by the viral polymerase through a stuttering mechanism.[RuleBase:RU362113]  Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated RIGI ubiquitination, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Prevents human EIF2AK2/PKR activation, either by binding double-strand RNA, or by interacting directly with EIF2AK2/PKR. This function may be important at the very beginning of the infection, when NS1 is mainly present in the cytoplasm. Also binds poly(A) and U6 snRNA.[RuleBase:RU362113]
-===Crystal structure of RNA-binding domain of NS1 from influenza A virus A/crow/Kyoto/T1/2004(H5N1)===
+==See Also==
+*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-Z0A is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z0A OCA].
+[[Category: Influenza A virus]]
-[[Category: Influenza a virus]]
+[[Category: Large Structures]]
-[[Category: Ito, H.]]
+[[Category: Ito H]]
-[[Category: Ito, T.]]
+[[Category: Ito T]]
-[[Category: Kamo-Uchikubo, T.]]
+[[Category: Kamo-Uchikubo T]]
-[[Category: Kishishita, S.]]
+[[Category: Kishishita S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Saijo S]]
-[[Category: Saijo, S.]]
+[[Category: Shirouzu M]]
-[[Category: Shirouzu, M.]]
+[[Category: Terada T]]
-[[Category: Terada, T.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Avian influenza]]
-[[Category: H5n1]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Ns1]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rna-binding]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Viral protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Nov 16 12:00:23 2008''