3e7g: Difference between revisions

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-{{Seed}}
-[[Image:3e7g.jpg|left|200px]]
-<!--
+==Structure of human INOSOX with inhibitor AR-C95791==
-The line below this paragraph, containing "STRUCTURE_3e7g", creates the "Structure Box" on the page.
+<StructureSection load='3e7g' size='340' side='right'caption='[[3e7g]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3e7g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7G FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT2:ETHYL+4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE'>AT2</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3e7g|  PDB=3e7g  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7g OCA], [https://pdbe.org/3e7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7g RCSB], [https://www.ebi.ac.uk/pdbsum/3e7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7g ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7g_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7g ConSurf].
+<div style="clear:both"></div>
-===Structure of human INOSOX with inhibitor AR-C95791===
+==See Also==
+*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-E7G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7G OCA].
 [[Category: Homo sapiens]]
-[[Category: Nitric-oxide synthase]]
+[[Category: Large Structures]]
-[[Category: Single protein]]
+[[Category: Aberg A]]
-[[Category: Aberg, A.]]
+[[Category: Andersson G]]
-[[Category: Andersson, G.]]
+[[Category: Andrews G]]
-[[Category: Andrews, G.]]
+[[Category: Arvai AS]]
-[[Category: Arvai, A S.]]
+[[Category: Cheshire DR]]
-[[Category: Cheshire, D R.]]
+[[Category: Connolly S]]
-[[Category: Connolly, S.]]
+[[Category: Crane BR]]
-[[Category: Crane, B R.]]
+[[Category: Garcin ED]]
-[[Category: Garcin, E D.]]
+[[Category: Gensmantel NP]]
-[[Category: Gensmantel, N P.]]
+[[Category: Getzoff ED]]
-[[Category: Getzoff, E D.]]
+[[Category: Hamley PJ]]
-[[Category: Hamley, P J.]]
+[[Category: Kroeger MD]]
-[[Category: Kroeger, M D.]]
+[[Category: Mallinder PR]]
-[[Category: Mallinder, P R.]]
+[[Category: Mete A]]
-[[Category: Mete, A.]]
+[[Category: Nicholls DJ]]
-[[Category: Nicholls, D J.]]
+[[Category: Rosenfeld RJ]]
-[[Category: Rosenfeld, R J.]]
+[[Category: St-Gallay SA]]
-[[Category: St-Gallay, S A.]]
+[[Category: Stueh DJ]]
-[[Category: Stueh, D J.]]
+[[Category: Tainer JA]]
-[[Category: Tainer, J A.]]
+[[Category: Tinker AC]]
-[[Category: Tinker, A C.]]
+[[Category: Wallace AV]]
-[[Category: Wallace, A V.]]
-[[Category: Alternative splicing]]
-[[Category: Calcium]]
-[[Category: Calmodulin-binding]]
-[[Category: Fad]]
-[[Category: Fmn]]
-[[Category: Heme]]
-[[Category: Iron]]
-[[Category: Metal-binding]]
-[[Category: Nadp]]
-[[Category: Nitric oxide]]
-[[Category: No]]
-[[Category: Oxidoreductase]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Tetrahydrobiopterin]]
-[[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  8 09:34:13 2008''