3e0d: Difference between revisions

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[[Image:3e0d.jpg|left|200px]]


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==Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit==
The line below this paragraph, containing "STRUCTURE_3e0d", creates the "Structure Box" on the page.
<StructureSection load='3e0d' size='340' side='right'caption='[[3e0d]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3e0d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E0D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene></td></tr>
{{STRUCTURE_3e0d| PDB=3e0d |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e0d OCA], [https://pdbe.org/3e0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e0d RCSB], [https://www.ebi.ac.uk/pdbsum/3e0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e0d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO3A_THEAQ DPO3A_THEAQ] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e0/3e0d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e0d ConSurf].
<div style="clear:both"></div>


===Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit===
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
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</StructureSection>
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[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18691598 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18691598}}
 
==About this Structure==
3E0D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E0D OCA].
 
==Reference==
Insights into the replisome from the structure of a ternary complex of the DNA polymerase III alpha-subunit., Wing RA, Bailey S, Steitz TA, J Mol Biol. 2008 Oct 17;382(4):859-69. Epub 2008 Jul 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18691598 18691598]
[[Category: DNA-directed DNA polymerase]]
[[Category: Protein complex]]
[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
[[Category: Bailey, S.]]
[[Category: Bailey S]]
[[Category: Steitz, T A.]]
[[Category: Steitz TA]]
[[Category: Wing, R A.]]
[[Category: Wing RA]]
[[Category: Beta barrel]]
[[Category: Cytoplasm]]
[[Category: Dna replication]]
[[Category: Dna-directed dna polymerase]]
[[Category: Nucleotidyl transferase]]
[[Category: Nucleotidyltransferase]]
[[Category: Ob fold]]
[[Category: Polymerase]]
[[Category: Transferase]]
[[Category: Transferase/dna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 10:44:02 2008''

Latest revision as of 12:43, 21 February 2024

Insights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunitInsights into the Replisome from the Crystral Structure of the Ternary Complex of the Eubacterial DNA Polymerase III alpha-subunit

Structural highlights

3e0d is a 6 chain structure with sequence from Thermus aquaticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 4.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPO3A_THEAQ DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3e0d, resolution 4.60Å

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