3dgc: Difference between revisions

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{{Seed}}
[[Image:3dgc.png|left|200px]]


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==Structure of IL-22/IL-22R1==
The line below this paragraph, containing "STRUCTURE_3dgc", creates the "Structure Box" on the page.
<StructureSection load='3dgc' size='340' side='right'caption='[[3dgc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3dgc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DGC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=U1:URANIUM+ATOM'>U1</scene></td></tr>
{{STRUCTURE_3dgc|  PDB=3dgc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dgc OCA], [https://pdbe.org/3dgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dgc RCSB], [https://www.ebi.ac.uk/pdbsum/3dgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dgc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IL22_HUMAN IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/3dgc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dgc ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22R1 also pairs with the IL-20R2 chain to induce IL-20 and IL-24 signaling. To define the molecular basis of these diverse interactions, we have determined the structure of the IL-22/sIL-22R1 complex. The structure, combined with homology modeling and surface plasmon resonance studies, defines the molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses.


===Structure of IL-22/IL-22R1===
Structure of IL-22 bound to its high-affinity IL-22R1 chain.,Jones BC, Logsdon NJ, Walter MR Structure. 2008 Sep 10;16(9):1333-44. Epub 2008 Jul 3. PMID:18599299<ref>PMID:18599299</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3dgc" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_18599299}}, adds the Publication Abstract to the page
*[[Interleukin 3D structures|Interleukin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 18599299 is the PubMed ID number.
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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== References ==
{{ABSTRACT_PUBMED_18599299}}
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
3DGC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DGC OCA].
 
==Reference==
Structure of IL-22 bound to its high-affinity IL-22R1 chain., Jones BC, Logsdon NJ, Walter MR, Structure. 2008 Sep 10;16(9):1333-44. Epub 2008 Jul 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18599299 18599299]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Jones, B C.]]
[[Category: Jones BC]]
[[Category: Logsdon, N J.]]
[[Category: Logsdon NJ]]
[[Category: Walter, M R.]]
[[Category: Walter MR]]
[[Category: Cytokine]]
[[Category: Cytokine/signaling protein complex]]
[[Category: Glycoprotein]]
[[Category: Il-22]]
[[Category: Il-22r1]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Secreted]]
[[Category: Signaling molecule]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 24 09:14:43 2008''

Latest revision as of 12:47, 6 November 2024

Structure of IL-22/IL-22R1Structure of IL-22/IL-22R1

Structural highlights

3dgc is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IL22_HUMAN Cytokine that contributes to the inflammatory response in vivo.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

IL-22 is an IL-10 family cytokine that initiates innate immune responses against bacterial pathogens and contributes to immune disease. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). IL-22R1 also pairs with the IL-20R2 chain to induce IL-20 and IL-24 signaling. To define the molecular basis of these diverse interactions, we have determined the structure of the IL-22/sIL-22R1 complex. The structure, combined with homology modeling and surface plasmon resonance studies, defines the molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses.

Structure of IL-22 bound to its high-affinity IL-22R1 chain.,Jones BC, Logsdon NJ, Walter MR Structure. 2008 Sep 10;16(9):1333-44. Epub 2008 Jul 3. PMID:18599299[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Jones BC, Logsdon NJ, Walter MR. Structure of IL-22 bound to its high-affinity IL-22R1 chain. Structure. 2008 Sep 10;16(9):1333-44. Epub 2008 Jul 3. PMID:18599299 doi:http://dx.doi.org/10.1016/j.str.2008.06.005

3dgc, resolution 2.50Å

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