1r1d: Difference between revisions

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New page: left|200px<br /><applet load="1r1d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r1d, resolution 2.00Å" /> '''Structure of a Carbo...
 
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[[Image:1r1d.jpg|left|200px]]<br /><applet load="1r1d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1r1d, resolution 2.00&Aring;" />
'''Structure of a Carboxylesterase from Bacillus stearothermophilus'''<br />


==About this Structure==
==Structure of a Carboxylesterase from Bacillus stearothermophilus==
1R1D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with EPE as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1R1D OCA].  
<StructureSection load='1r1d' size='340' side='right'caption='[[1r1d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
[[Category: Carboxylesterase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[1r1d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R1D FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r1d OCA], [https://pdbe.org/1r1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r1d RCSB], [https://www.ebi.ac.uk/pdbsum/1r1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r1d ProSAT], [https://www.topsan.org/Proteins/MCSG/1r1d TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/EST_GEOSE EST_GEOSE] Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/1r1d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r1d ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Carboxylesterase 3D structures|Carboxylesterase 3D structures]]
__TOC__
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Collart, F.]]
[[Category: Collart F]]
[[Category: Cuff, M.E.]]
[[Category: Cuff ME]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
[[Category: Zhou M]]
[[Category: Zhou, M.]]
[[Category: EPE]]
[[Category: bacillus stearothermophilus]]
[[Category: carboxylesterase]]
[[Category: mcsg]]
[[Category: midwest center for structural genomics]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:11:48 2007''

Latest revision as of 11:46, 6 November 2024

Structure of a Carboxylesterase from Bacillus stearothermophilusStructure of a Carboxylesterase from Bacillus stearothermophilus

Structural highlights

1r1d is a 2 chain structure with sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

EST_GEOSE Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1r1d, resolution 2.00Å

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