2j05: Difference between revisions

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-{{Seed}}
-[[Image:2j05.png|left|200px]]
-<!--
+==Crystal structure of the RasGAP SH3 domain at 1.5 Angstrom resolution==
-The line below this paragraph, containing "STRUCTURE_2j05", creates the "Structure Box" on the page.
+<StructureSection load='2j05' size='340' side='right'caption='[[2j05]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2j05]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J05 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
--->
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wer|1wer]], [[1wq1|1wq1]], [[2j06|2j06]]</div></td></tr>
-{{STRUCTURE_2j05|  PDB=2j05  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j05 OCA], [https://pdbe.org/2j05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j05 RCSB], [https://www.ebi.ac.uk/pdbsum/2j05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j05 ProSAT]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/2j05_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j05 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.
-===CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION===
+High resolution crystal structures of the p120 RasGAP SH3 domain.,Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236<ref>PMID:17188236</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2j05" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17188236}}, adds the Publication Abstract to the page
+*[[Ras GTPase activating protein|Ras GTPase activating protein]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17188236 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17188236}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Human]]
-J05 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA].
+[[Category: Large Structures]]
+[[Category: Gajhede, M]]
-==Reference==
+[[Category: Kristensen, O]]
-High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17188236 17188236]
+[[Category: Ross, B]]
-[[Category: Homo sapiens]]
-[[Category: Single protein]]
-[[Category: Gajhede, M.]]
-[[Category: Kristensen, O.]]
-[[Category: Ross, B.]]
 [[Category: Disease mutation]]
 [[Category: Gtpase activating protein]]
@@ Line 39: / Line 49: @@
 [[Category: Signal transduction]]
 [[Category: Src homology 3]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:47:53 2008''